Wet-adhesive materials of oral and maxillofacial region:From design to application

作     者：Yilin Mao Zhengyi Xu Zihan He Jian Wang Zhou Zhu Yilin Mao;Zhengyi Xu;Zihan He;Jian Wang;Zhou Zhu

作者机构：State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China West China School of StomatologySichuan UniversityChengdu 610041China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第1期

页      面：5-18页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.82101076,81771122,81970985) Key Research Program of Sichuan Science and Technology Department(No.2019YJ0147) Postdoctoral Research Foundation of China(No.2020M683334) 

主　　题：Oral cavity Oral and maxillofacial region Wet adhesion Stomatology Adhesive materials Mucoadhesion Tissue engineering 

摘      要：Oral and maxillofacial diseases are a group of high-incidence disorders that affect people’s life quality to a great extent,while the wet and highly movable environment of the related regions brings challenges to traditional *** with the obstacles of insufficient adhesive strength and ensuing short drug retention time,conventional oral therapeutic agents often have difficulty in achieving their desired *** and maxillofacial wet-adhesive materials have the advantages of excellent wet environment retention,internal stability,plasticity,and clinical potential,thus have become a significant research direction in the field of oral related disorders *** the past decade,the development of oral adhesive materials with good wet adhesion has accelerated based on the chemical molecular interaction,physical interlocking,and biological adhesion mechanisms,including biomimetic-inspired materials,naturally derived polymer–based materials and adhesive electrospun fiber *** fancy wet-adhesive materials can be used for oral mucosal drug delivery,oral vaccination,wound healing,and bone defects *** their numerous novel applications,wet-adhesive materials in stomatology still face unresolved challenges from material and biological ***,advances in designs of oral and maxillofacial wetadhesive materials are reviewed in terms of design backgrounds,attachment mechanisms,and common *** demonstrations of wet-adhesive materials for oral and maxillofacial region medical applications from drug delivery to multifunctional tissue treatments are *** conclude,current challenges and prospects on potential applications of oral and maxillofacial wet-adhesive materials are also briefly discussed.