Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion:stability evaluation

作     者：Luhui Wang Xinru Zhang Junxia Xiao Jiayi Shi Luhui Wang;Xinru Zhang;Junxia Xiao;Jiayi Shi

作者机构：College of Food Science and EngineeringQingdao Agricultural UniversityQingdao 266109China College of Food Science and EngineeringOcean University of ChinaQingdao 266109China College of Food Science and EngineeringNanjing University of Finance&EconomicsNanjing 210023China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第2期

页      面：555-563页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083203[工学-农产品加工及贮藏工程] 

基　　金：financial support from the Natural Science Foundation of Shandong Province(ZR2015CM037) the National Science Foundation of China(31571890)。 

主　　题：Curcumin Multilayered emulsion Layer-by-layer assembly Carboxymethyl konjac glucomannan Electrostatic interaction 

摘      要：The stability against various environmental stresses of the curcumin-loaded secondary and tertiary emulsions that was emulsified by whey protein isolate(WPI)and coated by chitosan(CHI),carboxymethyl konjac glucomannan(CMKGM),or their combination through layer-by-layer assembly was investigated.Generally,the multilayered emulsions were destabilized in high Na Cl concentrations or medium p H that could interrupt the electrostatic interaction between the three polyelectrolytes or deprotonate CHI,indicating that electrostatic interaction played an important role in the stability of emulsions.Compared with the primary emulsion that was solely stabilized by WPI,extra coating with CHI and CMKGM generally increased the stability of the emulsion against repeated freezing-thawing,improved the retention of curcumin against heating,UV irradiation,and long-term storage,and the effects were more remarkable in the tertiary emulsion with CMKGM locating in the outmost layer.Since CMKGM has shown the colon-targeted delivery potency,the multilayered emulsions assembled by layer-by-layer deposition,especially the tertiary emulsion,could be used as an effective carrier for the targeted delivery of curcumin.