Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis

作     者：ZHAO Shuai GUO Ying-ying DING Ning YANG Li-li ZHANG Ning 

作者机构：Department of Rheumatism Shengjing Hospital China Medical University Shenyang Liaoning 110004 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第19期

页      面：3058-3060页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 090601[农学-基础兽医学] 100704[医学-药物分析学] 1002[医学-临床医学] 09[农学] 0906[农学-兽医学] 10[医学] 

基　　金：This research was supported by a grant from the National Natural Science Foundation of China (No. 81072450) 

主　　题：rheumatoid arthritis osteoclast-associated receptor osteoclast 

摘      要：Background Osteoclast-associated receptor （OSCAR） is a member of the newly identified leukocyte receptor complex,and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor （sOSCAR） in the serum of rheumatoid arthritis （RA） patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory *** Enzyme-linked immunosorbent assay （ELISA） was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA *** The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory *** sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.