Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis
Changes in serum levels of soluble osteoclast-associated receptor in human rheumatoid arthritis作者机构:Department of Rheumatism Shengjing Hospital China Medical University Shenyang Liaoning 110004 China
出 版 物:《Chinese Medical Journal》 (中华医学杂志(英文版))
年 卷 期:2011年第124卷第19期
页 面:3058-3060页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 090601[农学-基础兽医学] 100704[医学-药物分析学] 1002[医学-临床医学] 09[农学] 0906[农学-兽医学] 10[医学]
主 题:rheumatoid arthritis osteoclast-associated receptor osteoclast
摘 要:Background Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex,and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory *** Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA *** The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory *** sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.