The Use of CT Perfusion to Determine Microvessel Density in Lung Cancer: Comparison with FDG-PET and Pathology

作     者：Ning Xing Zu-long Cai Shao-hong Zhao Li Yang Bai-xuan Xu Fu-lin Wang 

作者机构：Department of Radiology Department of Nuclear Medicine Department of Pathology China PLA General Hospital Beijing 100853 China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2011年第23卷第2期

页      面：118-122页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 08[工学] 071002[理学-动物学] 10[医学] 

基　　金：supported by grants from The National Key Technology R&D Program of China(No. 2009BAI86B00) Research in the Special Needs of Critical Care Technology and Equipment(No. 2009BAI86B05) PLA General Hospital Nursery Fund (No. 09KMM38) 

主　　题：Computed tomography (CT) Perfusion Positron-emission tomography (PET) Lung cancer angiogenesis 

摘      要：Objective： To investigate the validity of CT perfusion in assessing angiogenic activity of lung cancer. Methods： Fifty-six patients with lung cancer scheduled for elective surgical resection received 16-slice helical CT perfusion imaging. Time-density curve （TDC）, blood flow （BF）, blood volume （BV）, mean transmit time （MTT） and permeability surface area product （PS） were calculated. 18F-deoxyglucose-positron emission tomography （FGD-PET） was carried out in 14 out of the 56 patients to calculate standardized uptake values （SUVs）. Tumor microvessel density （MVD） was examined using CD34 immunohistochemical staining of the resected tumor tissue. Pearson’s correlation analysis was used to evaluate potential correlation between CT perfusion parameters and MVD or SUV. Results： Average time to peak height （TPH） of the TDCs （including two types of TDC） was 24.38±5.69 seconds. Average BF, BV, MTT and PS were 93.42±53.45 ml/100g/min,93.42±53.45 ml/100g,6.83±4.51 s and 31.92±18.73 ml/100g/min, respectively. Average MVD was 62.04±29.06/HPF. The mean SUV was 6.33±3.26. BF was positively correlated with MVD （r=0.620,P0.01） and SUV （r=0.891, P0.01）. PS was also positively correlated with SUV （r=0.720, P0.05）. A positive correlation was also observed between tumor MVD and SUV （r=0.915, P0.01）. Conclusions： CT perfusion imaging is a reliable tool to evaluate the tumor neovascularity of lung cancer.