A double-edged sword:The HBV-induced non-coding RNAs alterations in hepatocellular carcinoma

作     者：TIANXING LIU HONGYAN DIAO 

作者机构：Department of Cell and Systems BiologyUniversity of TorontoTorontoOntarioM5S1A1Canada State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310003China 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第1期

页      面：27-32页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the Key Research&Development Plan of Zhejiang Province(2019C04005) the National Key Research and Development Program of China(2018YFC2000500) 

主　　题：Non-coding RNA Hepatitis B virus Hepatocellular cancer 

摘      要：Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression,oncogenesis,and many other *** B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC),and some studies have shown that the expression of non-coding RNAs has an assignable effect on the development of HBV-induced *** this context,the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing *** review covers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNA expression,cataloging the recent reports about the roles of non-coding RNAs in HBV-induced hepatoma into five classes,including(1)modulation of metabolism in hepatic cancer,(2)aggravation of inflammation and hepatic fibrosis,(3)alteration of the tumor immune microenvironment,(4)non-coding RNA N6-methyladenosine modification,and a seemingly opposite process,(5)the suppression of the progression of HBV-related *** evidence supports non-coding RNAs as promising novel targets for the early diagnosis and treatments for HCC.