Olive oil ameliorate allergic response in ovalbumin-induced food allergy mouse by promoting intestinal mucosal immunity

作     者：Yu Ma Ming Liu Donghui Li Jie Li Zixin Guo Yunjun Liu Shengnan Wan Yixiang Liu Yu Ma;Ming Liu;Donghui Li;Jie Li;Zixin Guo;Yunjun Liu;Shengnan Wan;Yixiang Liu

作者机构：College of Ocean Food and Biological EngineeringJimei UniversityXiamen 361021China National Food and Strategic Reserves AdministrationBeijing 100083China Collaborative Innovation Center of Provincial and Ministerial Co-Construction for Marine Food Deep ProcessingDalian Polytechnic UniversityDalian 116034China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第3期

页      面：801-808页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083201[工学-食品科学] 

基　　金：supported by National Key Research and Development Program of China(2019YFC1605003-3) the Science and Technology Projects of Xiamen Science and Technology Bureau(3502Z20183034) 

主　　题：Olive oil Ovalbumin-induced food allergy Anti-food allergy Intestinal mucosal immunization 

摘      要：The numerous health benefits of olive oil are widely known,however,it also provides anti-allergic properties that have not yet been fully *** this study,the anti-allergic activity of olive oil was evaluated by analyzing the clinical symptoms and immune-related factors in BALB/c mice that had ingested600 mg/(kg·day)olive oil for two weeks prior to the *** allergy model was subsequently constructed for analysis,the results of which showed that the olive oil reduced the scores of allergic symptoms in the mice,and up-regulated the hypothermia and the decline in the immune organ ***,fewer allergy-related cytokines and reduced intestinal inflammation was discovered in the olive oil-treated *** addition,analysis of intestinal mucosal immune-related factors revealed that the olive oil promoted the expression of intestinal tight junction proteins(Claudin-1,Occludin,and ZO-1)and IL-22,and helped maintain the integrity of the intestinal epithelial physical *** levels of mucin 2 andβ-defensin were also found in the intestinal mucus of the olive oil-treated *** findings suggest that the oral administration of olive oil effectively attenuated the ovalbumin-induced allergic immune response in the mice,and had a positive effect on intestinal epithelial mucosal immunity.