Artificial simulated saliva,gastric and intestinal digestion and fermentation in vitro by human gut microbiota of intrapolysaccharide from Paecilomyces cicadae TJJ1213

作     者：Juanjuan Tian Xiaomeng Wang Xueliang Zhang Xiaohong Chen Mingsheng Dong Xin Rui Qiuqin Zhang Mei Jiang Wei Li Juanjuan Tian;Xiaomeng Wang;Xueliang Zhang;Xiaohong Chen;Mingsheng Dong;Xin Rui;Qiuqin Zhang;Mei Jiang;Wei Li

作者机构：College of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第2期

页      面：622-633页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 083201[工学-食品科学] 

基　　金：co-financed by National Natural Science Foundation of China(U1903108,31871771 and 31571818) Natural Science Foundation of Jiangsu Province(BK20201320) Jiangsu Agriculture Science and Technology Innovation Fund(CX(20)3043) Postgraduate Research&Practice innovation Program of Jiangsu Province(KYCX19_0589) Qing Lan Project of Jiangsu Province and Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) 

主　　题：Paecilomyces cicadae TJJ1213 Polysaccharide Fermentation Gut microbiota 

摘      要：In this study,the in vitro digestion and fermentation of two intra-polysaccharide fractions(IPS1 and IPS2)from Paecilomyces cicadae TJJ1213 were *** constituent monosaccharides of IPS1 and IPS2 were not changed after simulated saliva,gastric and small intestinal ***,they can be hydrolyzed and utilized by gut microbiota,and short-chain fatty acids(SCFAs)level were increased after IPS1 and IPS2 ***,16 S r RNA sequencing analysis of fermentation samples were ***-diversity,beta-diversity and taxonomic composition differences analysis revealed that IPS1 and IPS2 promoted the proliferation of beneficial bacteria and modulated the overall structure of gut *** comparison analysis found that IPS1 increased the relative abundances of beneficial bacteria including Megamonas,Bifidobacterium and Lactobacillus,while IPS2 could increase the abundance of Bacteroides,Parabacteroides and *** addition,they can also decrease the levels of pathogenic bacteria containing Escherichia-Shigella,Klebsiella and *** results indicated that IPS from Paecilomyces cicadae TJJ1213 could be used as potential candidates for new functional foods.