Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy
Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy作者机构：Institute of Radiology University Hospital Düsseldorf MNR Clinic Moorenstrasse 5 Düsseldorf 40225 Germany Department of Internal Medicine Division of Gastroenterology Hepatology and Infectious Diseases University Hospital Düsseldorf Moorenstrasse 5 Düsseldorf 40225 Germany
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2009年第15卷第41期
页 面：5157-5164页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：Brain Hepatic encephalopathy Magnetic resonance imaging Uver cirrhosis Magnetization transfer imaging
摘 要：AIM: To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).METHODS: Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxelbased ***: The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological defi cits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE.
维普期刊数据库