Liver histology in ICU patients dying from sepsis:A clinico-pathological study
Liver histology in ICU patients dying from sepsis:A clinico-pathological study作者机构：2nd Department of Internal MedicineAthens Medical SchoolAthens 11527Greece Laboratory of Surgical Research1st Department of Propaedeutic SurgeryAthens Medical SchoolAthens 11527Greece Laboratory of Histology and EmbryologyAthens Medical School Athens 11527Greece Laboratory of Surgical Research1st Department of Propaedeutic Surgery Athens Medical School Athens 11527Greece Intensive Care UnitHippocration HospitalAthens 11527Greece
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2008年第14卷第9期
页 面：1389-1393页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：AIM:To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit. METHODS: Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination. Liver function tests and clinical monitoring measurements were also recorded. RESULTS: Liver biochemistries were increased in the majority of patients before death. Histology of liver bi- opsy specimens showed portal inflammation in 73.3%, centrilobular necrosis in 80%, lobular inflammation in 66.7%, hepatocellular apoptosis in 66.6% and cholan- gitis/cholangiolitis in 20% of patients. Mixed hepatitic/ cholestatic type of liver injury was observed in 6/15 (40%) patients and hepatitc in 9/15 (60%). Steatosis was ob- served in 11/15 (73.3%) patients affecting 5%-80% of liver parenchyma. Among the histological features, the presence of portal inflammation in liver biopsy was as- sociated with increased hospitalization in the ICU prior death (P = 0.026). CONCLUSION: Features of hepatitis and steatosis arethe main histological findings in the liver in the majority of patients dying from sepsis.
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