Role of omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes on intestinal barrier integrity and immunity in animals

作     者：Tamil Selvi Sundaram Carlotta Giromini Raffaella Rebucci Juraj Pistl Mangesh Bhide Antonella Baldi Tamil Selvi Sundaram;Carlotta Giromini;Raffaella Rebucci;Juraj Pistl;Mangesh Bhide;Antonella Baldi

作者机构：Department of Veterinary Science for HealthAnimal Production and Food SafetyUniversity of MilanVia Trentacoste 220134 MilanItaly University of Veterinary Medicine and Pharmacy in KosiceKomenskeho 68/7304181 KosiceSlovakia 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2022年第13卷第5期

页      面：1240-1261页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：a European Joint Doctorate Degree programme in Molecular Animal Nutrition(MANNA)between University of Milan(Italy)and University of Veterinary Medicine and Pharmacy in Kosice(Slovakia) funding from the European Union’s Horizon 2020 programme under the Marie Slodowska-Curie Grant agreement No 765423. 

主　　题：Citrus pectin Immunomodulatory nutrients Inflammation Intestinal epithelial barrier Milk-derived exosomes Omega-3 polyunsaturated fatty acids Oxidative stress 

摘      要：The gastrointestinal tract of livestock and poultry is prone to challenge by feedborne antigens,pathogens,and other stress factors in the farm environment.Excessive physiological inflammation and oxidative stress that arises firstly disrupts the intestinal epithelial barrier followed by other components of the gastrointestinal tract.In the present review,the interrelationship between intestinal barrier inflammation and oxidative stress that contributes to the pathogenesis of inflammatory bowel disease was described.Further,the role of naturally existing immunomodulatory nutrients such as the omega-3 polyunsaturated fatty acids,citrus pectin,and milk-derived exosomes in preventing intestinal barrier inflammation was discussed.Based on the existing evidence,the possible molecular mechanism of these bioactive nutrients in the intestinal barrier was outlined for application in animal diets.