A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo
作者机构：CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Key Laboratory of Standardization and Measurement for NanotechnologyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China School of Nanoscience and TechnologySino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100049China Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative DiseasesSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China School of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan 430205China School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Center for AIE ResearchShenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第8期
页 面：7286-7294页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Natural Science Foundation of China(Nos.32027801,81801766,21775031,and 31870992) the Strategic Priority Research Program of Chinese Academy of Sciences(Nos.XDB36000000 and XDB38010400) Foundation of Chongqing Municipal Education Commission(No.HZ2021006) CAS-JSPS(No.GJHZ2094) Fujian Medical University Foundation for the Introduction of Talents(Nos.XRCZX2017020,XRCZX2019005,and XRCZX2019018) the Joint Funds for the innovation of science and Technology Fujian Province(No.2019Y9001)
主 题：programmed death 1(PD-1) targeting peptide self-assembly immune checkpoint blockade photothermal therapy
摘 要：Programmed death 1(PD-1)and its ligand PD-L1 are two typical immune ***-based immune checkpoint blockade(ICB)strategy targeting PD-1/PD-L1 achieved a significant therapeutic effect on ***,due to the impenetrability of antibody drugs and the occurrence of immune-related adverse events,only a minority of patients benefit from this *** multimerization has been widely proved to be an effective method to improve receptor binding affinity through a multivalent synergistic *** this study,we report a novel peptide-aggregation-induced emission(AIE)hybrid supramolecular TAP,which can self-assemble into nanofibers through non-covalent interactions such as hydrogen bonds,with a specific nanomolar affinity to PD-L1 in vivo and in *** with near-infrared agents,it can be used for tumor imaging and photothermal therapy,which enables photothermal ablation of cancer cells for generating tumor-associated antigen(TAA)and triggering a series of immunological ***,our work suggests that synthetic self-assembled peptide nanofibers can be developed as attractive platforms for active photothermal immunotherapies against cancer.
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