Nickel-Catalyzed Enantioselective C(sp^(3))–H Arylation of Ketones with Aryl Ethers via Selective C_(Ar)–O Cleavage to Construct All-Carbon Quaternary Stereocenters

作     者：Mingliang Li Jun(Joelle)Wang 

作者机构：Department of ChemistrySouthern University of Science and Technology(SUSTech)Shenzhen 518055 Department of ChemistryHong Kong Baptist UniversityKowloonHong Kong 999077 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2022年第4卷第9期

页      面：2921-2929页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(no.NSFC 21902072)and the Guangdong Innovative Program(no.2019BT02Y335)for their financial support 

主　　题：nickel catalysis asymmetric arylation C–O cleavage aryl pyrimidyl ether all-carbon quaternary stereocenter 

摘      要：We designed thenickel-catalyzed enantioselective C(sp^(3))–H arylation of ketones with phenol-derived aryl pyrimidyl ethers via selective cleavage of the C(aryl)–O bond to construct all-carbon quaternary *** method exhibits good functional group compatibility and broad substrate *** molecule donepezil can directly transform into corresponding highly optically pure derivatives with this *** studies reveal that C(aryl)–O cleavage of aryl pyrimidyl ether probably proceeded by means of an anionic organo-Ni(0)intermediate.