In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles

作     者：Liqin Ren Yang Liu Tingfeng Yao Kytai TNguyen Baohong Yuan Liqin Ren;Yang Liu;Tingfeng Yao;Kytai T.Nguyen;Baohong Yuan

作者机构：Ultrasound and Optical Imaging LaboratoryDepartment of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Programthe University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2023年第16卷第1期

页      面：1009-1020页

核心收录：

学科分类：081704[工学-应用化学] 1002[医学-临床医学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学] 

基　　金：This work was supported in part by funding from the National Institute of Biomedical Imaging and Bioengineering(No.1R15EB030809-01) the Research Enhancement Program(No.270089) the Cancer Prevention&Research Institute of Texas(Nos.RP170564 and RP210206) 

主　　题：in vivo tumor imaging deep tissue near-infrared(NIR)imaging high resolution ultrasound-switchable fluorescence imaging indocyanine green(ICG) 

摘      要：Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment *** particular,ultrasound switchable fluorescence(USF)imaging has been explored with improved imaging sensitivity and spatial resolution in centimeter-deep *** study achieved the size control of polymer-based and indocyanine green(ICG)encapsulated USF contrast agents,capable of accumulating in the tumor after intravenous *** nanoprobes varied in size from 58 to 321 *** bioimaging profiles demonstrated that the proposed nanoparticles can efficiently eliminate the background light from normal tissue and show a tumor-specific fluorescence enhancement in the BxPC-3 tumor-bearing mice models possibly via the enhanced permeability and retention *** vivo tumor USF imaging further demonstrated that these nanoprobes can effectively be switched“ONwith enhanced fluorescence in response to a focused ultrasound stimulation in the tumor microenvironment,contributing to the high-resolution USF ***,our findings suggest that ICG-encapsulated nanoparticles are good candidates for USF imaging of tumors in live animals,indicating their great potential in optical tumor imaging in deep tissue.