Nanofiber self-consistent additive manufacturing process for 3D microfluidics
作者机构：Fujian Micro/Nano Manufacturing Engineering Technology Research CenterXiamen UniversityXiamen 361102China School of Mechanical and Electrical EngineeringLingnan Normal UniversityZhanjiang 524000China
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2022年第8卷第5期
页 面：239-246页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：supported by the National Natural Science Foundation of China(No.51975498,No.U2005214,NO.52005239) the Guangdong Basic and Applied Basic Research Foundation(NO.2019A1515110637)
摘 要：3D microfluidic devices have emerged as powerful platforms for analytical chemistry,biomedical sensors,and microscale fluid manipulation.3D printing technology,owing to its structural fabrication flexibility,has drawn extensive attention in the field of 3D microfluidics ***,the collapse of suspended structures and residues of sacrificial materials greatly restrict the application of this technology,especially for extremely narrow channel *** this paper,a 3D printing strategy named nanofiber self-consistent additive manufacturing(NSCAM)is proposed for integrated 3D microfluidic chip fabrication with porous nanofibers as supporting structures,which avoids the sacrificial layer release *** the NSCAM process,electrospinning and electrohydrodynamic jet(E-jet)writing are alternately *** porous polyimide nanofiber mats formed by electrospinning are ingeniously applied as both supporting structures for the suspended layer and percolating media for liquid flow,while the polydimethylsiloxane E-jet writing ink printed on the nanofiber mats(named construction fluid in this paper)controllably permeates through the porous *** curing,the resultant construction fluid–nanofiber composites are formed as 3D channel *** a proof of concept,a microfluidic pressure-gain valve,which contains typical features of narrow channels and movable membranes,was fabricated,and the printed valve was totally closed under a control pressure of 45 kPa with a fast dynamic response of 52.6 ms,indicating the feasibility of ***,we believe NSCAM is a promising technique for manufacturing microdevices that include movable membrane cavities,pillar cavities,and porous scaffolds,showing broad applications in 3D microfluidics,soft robot drivers or sensors,and organ-on-a-chip systems.
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