Cytarabine delivered by CD44 and bone targeting redox-sensitive liposomes for treatment of acute myelogenous leukemia

作     者：Hao Wu Yuan Gao Jia Ma Maosong Hu Jing Xia Shuting Bao Yuxi Liu Kai Feng 

作者机构：College of Materials&Chemical EngineeringChuzhou UniversityChuzhou 239000China Department of OncologyBeijing Shunyi HospitalShunyi DistrictBeijing 101300China Department of NeurologyBeijing Shunyi HospitalShunyi DistrictBeijing 101300China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2022年第9卷第1期

页      面：750-760页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Chuzhou University Scientific Research Fund(2020qd50,2022XJYB10) the Key Research and Development Program of Anhui Province(202104b11020010) the Students’Innovation and Entrepreneurship Training Program of Anhui Province(S202110377140) 

主　　题：cytarabine liposomes acute myeloid leukemia hyaluronic acid 

摘      要：Acute myelogenous leukemia(AML)remains a serious fatal disease for the patients and effective treatment strategies are urgently *** on the characteristics of the AML,we developed the CD44 and bone targeting liposomes delivery system decorated with the redox-cleavable ***,ALN-HA was obtained by amination between alendronate(ALN)and hyaluronic acid(HA),and cholesterol(Chol)was coupled by a disulfide linker(-SS-)with biological reducibility to obtain the goal polymer,ALN-HA-SS-Chol,decorated the liposomes loaded with the Cytarabine(AraC).ALN-HA-SS-AraC-Lip exhibited a spherical morphology with the diameter of 117.5nm and expanded at the environment of 10mM ***,compared with other groups,ALN-HA-SS-AraC-Lip showed benign hydroxyapatite affinity in vitro and bone targeting in C57/BL6 mice,also,ALN-HA-SS-AraC-Lip exhibited encouraging antitumor which significantly reduced the white blood cell amount in bone marrow and blood smear caused by AML model,besides,the dual targeting liposomes also prolong the survival time of *** conclusion,the bone and CD44 dual targeting liposomes with redox sensitivity could target to the leukemia stem cells regions and then uptake by the tumor cells,which would be a valuable target for the treatment of the AML.