Human bocavirus infection in children hospitalized with lower respiratory tract infections:Does viral load affect disease course?

作     者：Ayşe Karaaslan CerenÇetin Serap Demir Tekol Ufuk Yükselmiş Mehmet Tolga Köle Yasemin Akın Ay?e Karaaslan;Ceren ?etin;Serap Demir Tekol;Ufuk Yükselmi?;Mehmet Tolga K?le;Yasemin Ak?n

作者机构：Department of Pediatric Infectious DiseasesUniversity of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey Department of MicrobiologyUniversity of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey Department of Pediatric Intensive Care UnitUniversity of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey Department of PediatricsUniversity of Health SciencesKartal Dr.Lütfi Kırdar City HospitalIstanbulTurkey 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2022年第15卷第8期

页      面：354-360页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Human bocavirus Lower respiratory tract infection Children Viral load 

摘      要：Objective:To examine the effects of human bocavirus type 1(HBoV1)on the course of lower respiratory tract infections in cases of monoinfection and coinfection,and the effects of HBoV1 viral load on the disease in children under six years old hospitalized with a diagnosis of HBoV1-associated lower respiratory tract ***:Children under six years of age,who were hospitalized with the diagnosis of lower respiratory tract infection due to HBoV1 between 1 January 2021 and 1 January 2022 were included in the *** confirmation of the respiratory pathogens was performed using polymerase chain reaction(PCR).Results:Fifty-four(16.4%)children with HBoV1 among 329 children whose PCR was positive with bacterial/viral agent in nasopharyngeal swab samples were included in the *** were 28(51.9%)males and 26(48.1%)females with a median age 23.4 months[interquartile range(IQR):13.2,30.0 months](min-max:1 month-68 months).HBoV1 was detected as a monoinfecton in 26(48.1%)children,and as a coinfection with other respiratory agents in 28 children(51.9%).In multiple regression analysis,coinfection(P=0.032)was associated with the length of hospitalization(P0.001;R^(2)=0.166).There was a negative correlation(r=−0.281,P=0.040)between cough and cycle *** was found to be positively correlated with C-reactive protein(r=0.568,P0.001)and procalcitonin(r=0.472;P=0.001).Conclusions:Although we found a higher HBoV1 viral load in children with more cough symptoms in our study,it had no effect on the severity of the disease,such as length of hospital stay and need for intensive *** was found to affect the length of hospitalization.