The regulatory variant rs17612742 confers the risk of large artery atherosclerotic stroke by increasing the expression of endothelin receptor type A
作者机构：School of MedicineSoutheast UniversityNanjingJiangsu 210009China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan ProvinceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life ScienceUniversity of Chinese Academy of SciencesKunmingYunnan 650204China Department of NeurosurgeryThe Second Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650101China Department of geriatric psychiatryNanjing Brain Hospital Affiliated to Nanjing Medical UniversityNanjingJiangsu 210024China Department of Cerebrovascular DiseaseShanghai Fourth People’s Hospital affiliated to Tongji University School of MedicineShanghai 200000China School of PharmacyWannan Medical CollegeWuhuAnhui 241000China Department of NeurologyFirst Affiliated Hospital of Wannan Medical CollegeWuhuAnhui 241000China Yunnan Clinical Research Center for Mental Disordersthe first Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China
出 版 物：《Life Research》 (TMR生命研究)
年 卷 期：2022年第5卷第4期
页 面：27-35页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：large artery atherosclerotic stroke rs17612742 EDNRA
摘 要：Genome-wide association studies have found that rs17612742 increases the risk of large artery atherosclerotic *** rs17612742 was located in the intron region of Endothelin receptor type A(NRA),which was cellular and *** genomics studies of rs17612742 were carried out through some public databases,and it was found that rs17612742 was located in the chromatin open region and promoted the expression of *** with the control group,EDNRA expression increased in middle cerebral artery occlusion exposed ***,age heterogeneity of EDNRA expression under physiological and pathological conditions was not *** addition,we also discussed how to conduct further empirical studies to provide evidence that rs17612742 confers the risk of large artery atherosclerotic stroke by increasing the expression of NRA.
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