Combination of C-reactive protein and fibrinogen is useful for diagnosing periprosthetic joint infection in patients with inflammatory diseases

作     者：Hong Xu Jinwei Xie Xufeng Wan Li Liu Duan Wang Zongke Zhou Hong Xu;Jinwei Xie;Xufeng Wan;Li Liu;Duan Wang;Zongke Zhou

作者机构：Department of Orthopedic SurgeryOrthopedic Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Orthopedic SurgeryWest China School of NursingWest China HospitalSichuan UniversityChengduSichuan 610041China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第16期

页      面：1986-1992页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYJC18039) the Sichuan University postdoctoral interdisciplinary Innovation Fund,and Post-Doctor Research Project,West China Hospital,Sichuan University(2020HXBH080) 

主　　题：Periprosthetic joint infection C-reactive protein Fibrinogen Diagnosis Revision arthroplasty 

摘      要：Background:The screening of periprosthetic joint infection(PJI)in patients with inflammatory diseases before revision arthroplasty remains *** C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),plasma fbrinogen(FIB),monocyte/lymphocyte ratio,and neutrophil/lymphocyte ratio(NLR)can help screening PJI,but their values in patients with infammatory diseases have not been ***:Patients with inflammatory diseases who underwent revision hip or knee arthroplasty at West China Hospital,Sichuan University,from January 2008 to September 2020 were divided into infected and non-infected groups based on the 2013 International Consensus Meeting *** and specificity of the tested biomarkers for diagnosing infection were determined based on receiver operating characteristic(ROC)curves,and optimal cutoffs were determined based on the Y ouden *** diagnostic ability of these biomarkers was re-assessed after combining them with each ***:A total of 62 patients with inflammatory diseases were studied;of them 30 were *** area under the ROC curve was 0.813 for CRP,0.638 for ESR,0.795 for FIB,and 0.656 for *** optimal predictive cutoff of CRP was 14.04 mg/L with a sensitivity of 86.2%and a specificity of 68.7%,while FIB had a sensitivity of 72.4%and a specificity of 81.2%with the optimal predictive cutoff of 4.04 g/*** combinations of CRP with FIB produced a sensitivity of 86.2%and specificity of 78.1%.Conclusion:CRP with a slightly higher predictive cutoff and FIB are useful for screening PJI in patients with inflammatory diseases,and the combination of CRP and FIB may further improve the diagnostic values.