Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma:An overlooked conjugation

作     者：JOÃO OLIVEIRA PEREIRA JOÃO GAMA DIANA FERREIRA ARSÉNIO SANTOS 

作者机构：Pulmonology DepartmentCoimbra Hospital and University CentreCoimbra3004-561Portugal Faculty of Medicine of the University of CoimbraCoimbra3000-370Portugal Anatomical Pathology DepartmentCoimbra Hospital and University CentreCoimbra3004-561Portugal Internal Medicine DepartmentCoimbra Hospital and University CentreCoimbra3004-561Portugal 

出 版 物：《Oncology Research》 (肿瘤学研究（英文）)

年 卷 期：2021年第29卷第2期

页      面：81-85页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Hypercalcaemia-leukocytosis syndrome adenosquamous lung carcinoma skull metastases percutaneous lymph node biopsy 

摘      要：Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor *** carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma and squamous cell *** report the case of a 57-year-old male smoker who was admitted to the Emergency Room with skull and neck tumefactions,confusion and deteriorated general *** complementary study in the ER revealed severe hypercalcaemia(19.8 mg/dL),leukocytosis(18.7×10^(9)/L)and extensive osteolytic lesions of the skull on cranioencephalic computer tomography(CT).The patient was stabilized and *** CT showed lung parenchyma consolidation with necrotic areas,supra and infradiaphragmatic adenopathies and scattered osteolytic *** lymph node biopsy was consistent with metastasis of adenosquamous lung *** patients’clinical situation evolved unfavourably after hospital-acquired *** case is characterized by a rare presentation of advanced stage adenosquamous lung carcinoma with scattered osteolytic lesions and severe hypercalcaemia-leukocytosis syndrome,an underrecognized marker of poor prognosis.