Nitric oxide negatively regulates gibberellin signaling to coordinate growth and salt tolerance in Arabidopsis

作     者：Lichao Chen Shuhao Sun Chun-Peng Song Jian-Min Zhou Jiayang Li Jianru Zuo Lichao Chen;Shuhao Sun;Chun-Peng Song;Jian-Min Zhou;Jiayang Li;Jianru Zuo

作者机构：State Key Laboratory of Plant GenomicsInstitute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China College of Advanced Agricultural SciencesUniversity of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesBeijing 100101China State Key Laboratory of Crop Stress Adaptation and ImprovementCollaborative Innovation Center of Crop Stress BiologyHenan UniversityKaifengHenan 475001China Hainan Yazhou Bay Seed LaboratorySanyaHainan 572025China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第8期

页      面：756-765页

核心收录：

学科分类：0710[理学-生物学] 09[农学] 0903[农学-农业资源与环境] 

基　　金：supported by grants from the National Natural Science Foundation of China (31830017 and 31521001) Chinese Academy of Sciences (XDB27030207) State Key Laboratory of Plant Genomics (SKLPG2020-22) 

主　　题：Gibberellin Nitric oxide S-nitrosylation DELLA repressors Stress responses 

摘      要：In response to dynamically altered environments,plants must finely coordinate the balance between growth and stress responses for their survival.However,the underpinning regulatory mechanisms remain largely elusive.The phytohormone gibberellin promotes growth via a derepression mechanism by proteasomal degradation of the DELLA transcription repressors.Conversely,the stress-induced burst of nitric oxide(NO)enhances stress tolerance,largely relying on NO-mediated S-nitrosylation,a redox-based posttranslational modification.Here,we show that S-nitrosylation of Cys-374 in the Arabidopsis RGA protein,a key member of DELLAs,inhibits its interaction with the F-box protein SLY1,thereby preventing its proteasomal degradation under salinity condition.The accumulation of RGA consequently retards growth but enhances salt tolerance.We propose that NO negatively regulates gibberellin signaling via S-nitrosylation of RGA to coordinate the balance of growth and stress responses when challenged by adverse environments.