Structural insights into the Omicron spike trimer:tackling the challenges of continuously evolving SARS-CoV-2 variants

作     者：Junxian Ou Jianguo Wu Qiwei Zhang 

作者机构：Guangdong Provincial Key Laboratory of VirologyInstitute of Medical MicrobiologyJinan University510632 GuangzhouChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第10期

页      面：3625-3627页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Key Research and Development Program of China(2018YFE0204503) National Natural Science Foundation of China(32170139 and 81730061) Natural Science Foundation of Guangdong Province(2021A1515010788 and 2022A1515011190) the Fundamental Research Funds for the Central Universities(21622101) 

主　　题：ACE2 insight continuously 

摘      要：The recent studies published in Science and Cell Research investigated the structures and biochemical mechanism of the SARS-CoV-2 Omicron BA.1 and BA.2 spike trimer with ACE2 as well as an effective antibody JMB2002 against BA.1 and BA.2 spike,which provide new insights for the global development of broadspectrum anti-SARS-CoV-2 antibodies and vaccines.