Prevalence of precancerous lesions and conditions in India: A systematic review and meta-analysis

作     者：Abhishek Kumbhalwar Sahana Hegde Shetiya Pradnya Kakodkar Vini Mehta Ankita Mathur Priyanka Porwal 

作者机构：Department of Public Health DentistryD.Y.Patil Dental SchoolCharholiLohegaonPune 412105India Department of Public Health DentistryDr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPimpriPune 411018India Dr.D.Y.Patil VidyapeethPimpriPune 411018India Public HealthSTAT SENSEGandhinagar 382421India 

出 版 物：《World Journal of Methodology》 (世界方法学杂志)

年 卷 期：2022年第12卷第4期

页      面：293-304页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Prevalence Pre-cancerous lesion Pre-cancerous condition India 

摘      要：BACKGROUND Smoking and chewing tobacco are associated with numerous oral mucosal lesions and conditions,often leading to cancer *** To investigate the prevalence of precancerous lesions and conditions among the Indian *** Systematic search was conducted for population or community-based observational epidemiological studies in PubMed,EMBASE,Web of Science,IndMED,Google Scholar,reports of the WHO South-East Asia Region,MOHFW India reports,Science Citation Index,WHO Index Medicus of the South-East Asian Region,Reference Citation Analysis(https://***/)and Open Grey from the earliest available up to 31st January *** effect size was calculated for the prevalence of precancerous lesions and *** One hundred sixty-two estimates from 130 studies yielded 52 high,71 moderate,and seven low-quality studies from *** estimate based on crosssectional studies for leukoplakia was 4.3%(95%CI:4.0-4.6),oral submucous fibrosis was 2.7%(95%CI:2.5-3.0),palatal lesions in reverse smokers and nicotine palatine were 5.8%(95%CI:4.4-7.2),and Erythroplakia was 1.2%(95%CI:0.7-1.7),and lichen planus was 1.1%(95%CI:0.9-1.2).Amongst hospital-based studies,the pooled prevalence for Leukoplakia was 6.7%(95%CI:6.0-7.3),oral submucous fibrosis was 4.5%(95%CI:4.2-4.9),lichen planus was 7.5%(95%CI:5.3-9.6),and erythroplakia was 2.5%(95%CI:0.4-4.5),and palatal lesions in reverse smokers and nicotine palatini were 11.5%(95%CI:8.0-15.0).CONCLUSION Precancerous lesions and conditions are prevailing problems among the Indian *** is mainly due to tobacco use,the smokeless form of *** meta-analysis indicates that hospital-based studies have a higher effect size of 6.7%than community-based *** who have already developed this condition may be advised to reduce their exposure to the risk factor to prevent the condition from progressing further.