Viral Tools for Neural Circuit Tracing
作者机构：The Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsKey Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of SciencesBeijing 100049China
出 版 物：《Neuroscience Bulletin》 (神经科学通报(英文版))
年 卷 期：2022年第38卷第12期
页 面：1508-1518页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：This review was supported by the National Science and Technology Innovation 2030(2021ZD0201003) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200) the National Natural Science Foundation of China(31830035) the Shenzhen Key Laboratory of Viral Vectors for Biomedicine(ZDSYS20200811142401005)
主 题：Neural circuit Viral tool Anterograde Retrograde Trans-synaptic
摘 要：Neural circuits provide an anatomical basis for functional ***,dissecting the structure of neural circuits is essential to understanding how the brain *** neurotropic viruses are important tools for neural circuit tracing with many advantages over non-viral tracers:they allow for anterograde,retrograde,and trans-synaptic delivery of tracers in a cell type-specific,circuit-selective *** this review,we summarize the recent developments in the viral tools for neural circuit tracing,discuss the key principles of using viral tools in neuroscience research,and highlight innovations for developing and optimizing viral tools for neural circuit tracing across diverse animal species,including nonhuman primates.
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