Mechanism Study on Chinese Medicine in Treatment of Nodular Goiter

作     者：WANG Chang-lin GAO Ming-zhou GAO Xiang-ju MU Xiang-yu WANG Jie-qiong GAO Dong-mei QIAO Ming-qi WANG Chang-lin;GAO Ming-zhou;GAO Xiang-ju;MU Xiang-yu;WANG Jie-qiong;GAO Dong-mei;QIAO Ming-qi

作者机构：School of Chinese MedicineShandong University of Traditional Chinese MedicineJinan(250355)China Research and Innovation Team of Emotional Diseases and Syndromes of Shandong University of Traditional Chinese MedicineJinan(250355)China Key Laboratory of Traditional Chinese Medicine for Classical TheoryMinistry of EducationJinan(250355)China School of PharmacyShandong University of Traditional Chinese MedicineJinan(250355)China Youth Research and Innovation Team of Pharmacology of Liver Viscera in Emotional Disease and SyndromesJinan(250355)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2023年第29卷第6期

页      面：566-576页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by Jinan 20 Items in Universities"Funded Project(No.2020GXRC002)。 

主　　题：noduiar goiter Chinese medicine mechanism pharmacology review 

摘      要：Nodular goiter has become increasingly prevalent in recent years.Clinically,there has been a burgeoning interest in nodular goiter due to the risk of progression to thyroid cancer.This review aims to provide a comprehensive summary of the mechanisms underlying the therapeutic effect of Chinese medicine(CM)in nodular goiter.Articles were systematically retrieved from databases,including PubMed,Web of Science and China National Knowledge Infrastructure.New evidence showed that CM exhibited multi-pathway and multi-target characteristics in the treatment of nodular goiter,involving hypothalamus-pituitary-thyroid axis,oxidative stress,blood rheology,cell proliferation,apoptosis,and autophagy,especially inhibition of cell proliferation and promotion of cell apoptosis,involving multiple signal pathways and a variety of cytokines.This review provides a scientific basis for the therapeutic use of CM against nodular goiter.Nonetheless,future studies are warranted to identify more regulatory genes and pathways to provide new approaches for the treatment of nodulargoiter.