Molecular factors,diagnosis and management of gastrointestinal tract neuroendocrine tumors:An update
作者机构:Department of 2^(nd) Surgical PropedeuticHippocration HospitalAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece Department of 2^(nd) Surgical PropedeuticAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece
出 版 物:《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期:2022年第10卷第27期
页 面:9573-9587页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:Gastrointestinal neuroendocrine tumors Neuroendocrine neoplasms Mixed NEN Neuroendocrine carcinoma APUD cells Carcinoids Somatostatin analogs
摘 要:The prevalence of gastrointestinal neuroendocrine tumors(GI-NETs) is increasing,and despite recent advances in their therapy,it remains inadequate in patients with advanced well-differentiated neuroendocrine *** tumors present many challenges concerning the molecular basis and genomic profile,pathophysiology,clinicopathological features,histopathologic classification,diagnosis and *** has been an ongoing debate on diagnostic criteria and clinical behavior,and various changes have been made over the last few *** carcinoma of the gastrointestinal system is a rare but highly malignant neoplasm that is genetically distinct from gastrointestinal system neuroendocrine tumors(NETs).The diagnosis and management have changed over the past *** novel biomarkers and metabolic players in cancer cells are useful and promising new diagnostic *** in positron emission tomography-computerized tomography and scintigraphy with new radioactive agents(^(64)Cu-DOTATATE or ^(68)Ga-DOTATATE) replacing enough octreoscan,has improved further the current diagnostic *** results provide targeted therapies with biological agents,new drugs,chemotherapy and ***,the role of surgery is important,since it is the cornerstone of *** resection of small bowel NETs with synchronous liver metastases is a surgical *** offers novel options not only for diagnosis but also for interventional *** therapeutic option should be individualized based on current multidisciplinary information.