Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer

作     者：Qiongzhe Ren Xuefeng Tang Yi Lu Qing Li Zhiqian Liao Shinan Jiang Haoli Zhang Zhigang Xu Lei Luo Qiongzhe Ren;Xuefeng Tang;Yi Lu;Qing Li;Zhiqian Liao;Shinan Jiang;Haoli Zhang;Zhigang Xu;Lei Luo

作者机构：College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Department of PathologyChongqing General HospitalUniversity of Chinese Academy of SciencesChongqing 401120China School of Materials and Energy and Chongqing Engineering Research Center for Micro–Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China State Key Laboratory of Applied Organic Chemistry(SKLAOC)College of Chemistry and Chemical EngineeringKey Laboratory of Special Function Materials and Structure Design(MOE)Lanzhou UniversityLanzhou 730000China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2022年第17卷第4期

页      面：596-609页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100602[医学-中西医结合临床] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Key Research and Development Program of China(2021YFD1800900) National Natural Science Foundation of China(82073790) Science and Technology Research Project of Chongqing Education Commission(KJQN202100229) 

主　　题：Nanocrystal Stabilizer-free Stimuli-responsive Drug delivery Combination therapy 

摘      要：The use of nanocrystal technology to manufacture drug delivery systems intended to enhance therapeutic efficacy has attracted the attention of the pharmaceutical ***,the clinical application of nanocrystal drugs for injection is restricted by Ostwald ripening and the large-scale use of stabilizers such as polysorbate and lecithin,which have potential toxicity risks including hemolysis and ***,we designed an amorphous nanocrystal drug complex(IHNC),which is stabilizer-free and composed of indocyanine green(ICG)framework loading with a chemotherapeutic agent of 10-hydroxycamptothecin(HCPT).Considering the possibility of industrial manufacturing,IHNC was simply prepared with the assistance of ferric ion(III)via supramolecular assembly *** theoretical result of Materials Studio simulation indicated that the prepared ICG-Fe(III)framework showed a stable spherical structure with the appropriate cavity for encapsulating the two drugs of HCPT and ICG with equal mass *** IHNC was stable at physiological pH,with excellent PTT/PDT efficacy,and in vivo probing *** nanoscale size and reductive stimuli-responsiveness can be conducive to drug accumulation into the tumor site and rapid unloading of ***,such combination therapy showed synergistic photo/chemotherapy effect against 4T1 breast cancer and its tumor inhibition rate even up to 79.4%.These findings demonstrated that the nanocrystal drug delivery strategy could avoid the use of stabilizers and provide a new strategy for drug delivery for combination therapy.