Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies

作     者：Wuyin Wang Lu Zhang Zhijun Sun Wuyin Wang;Lu Zhang;Zhijun Sun

作者机构：The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool&Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral Maxillofacial-Head Neck OncologySchool&Hospital of StomatologyWuhan UniversityWuhan 430079China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第7期

页      面：948-964页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China 82072996(Z.S.),81874131(Z.S.),82170941(L.Z.) National Key Research and Development Program(2017YFSF090107) the Innovative research team of high-level local universities in Shanghai ZLCX20180500(Z.S.). 

主　　题：Pyroptosis immune checkpoint blockade immunogenic cell death tumor immunotherapy 

摘      要：Immune checkpoint blockade(ICB)therapy has recently shown promise in treating several malignancies.However,only a limited number of patients respond to this treatment,partially because of the“immune coldcondition of the tumor immune microenvironment.Pyroptosis is a type of gasdermin-mediated programmed cell death that often leads to inflammation and immune responses.Many studies on the mechanism and function of pyroptosis have led to increasing recognition of the role of pyroptosis in malignant progression and immune therapy.Pyroptosis has the potential to alter the tumor immune microenvironment by releasing tumor-associated antigens,damage-associated molecular patterns,and proinflammatory cytokines,thus leading to intratumoral inflammatory responses,stimulation of tumor-specific cytotoxic T cell infiltration,conversion of“coldto“hottumors,and ultimately improving the efficacy of ICB therapy.Some cancer treatments have been shown to restore anticancer immunosurveillance through the induction of pyroptosis.Therapy promoting pyroptosis and ICB therapy may have synergistic effects in cancer treatment.This review summarizes the mechanisms and roles of pyroptosis in the tumor microenvironment and combination treatment strategies.An improved understanding of the roles of pyroptosis in tumorigenesis,immune evasion,and treatment would aid in the development of therapeutic strategies for malignancies.