Increased 5-hydroxymethylcytosine is a favorable prognostic factor of Helicobacter pylori-negative gastric cancer patients

作     者：Ying-Li Fu Yan-Hua Wu Dong-Hui Cao Zhi-Fang Jia Ao Shen Jing Jiang Xue-Yuan Cao 

作者机构：Division of Clinical ResearchThe First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Gastric and Colorectal SurgeryThe First Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第7期

页      面：1295-1306页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China,No.81874279 Scientific and Technological Development Program of Jilin Province,No.20190201093JC and No.20200201326JC Jilin Province Department of Finance,No.JLSWSRCZX2020-010 Youth Development Fund from First Hospital of Jilin University,No.JDYY11202021 

主　　题：5-hydroxymethylation 5-hydroxymethylcytosine Helicobacter pylori Gastric cancer Prognosis 

摘      要：BACKGROUND Most gastric cancer(GC)patients are diagnosed at middle or late stage because the symptoms in early stage are obscure,which causes higher mortality rates of *** pylori(***)was identified as a class I carcinogen and leads to aberrant DNA methylation/hydroxymethylation.5-hydroxymethylcytosine(5-hmC)plays complex roles in gene regulation of tumorigenesis and can be considered as an activating epigenetic mark of *** To explore the association between 5-hmC levels and the progression and prognosis of GC patients with or without *** *** A retrospective cohort study was conducted to estimate the predicted value of 5-hmC level in the progression and prognosis of GC patients with different *** infection status.A total of 144 GC patients were *** The levels of 5-hmC were significantly decreased in tumor tissues(0.076±0.048)compared with the matched control tissues(0.110±0.057,P=0.001).A high level of 5-hmC was an independent significant favorable predictor of overall survival in GC patients(hazard ratio=0.61,95% confidence interval:0.38-0.98,P=0.040),the ***-negative GC subgroup(hazard ratio=0.30,95% confidence interval:0.13-0.68,P=0.004)and the GC patients with TNM stage Ⅰ or Ⅱ(hazard ratio=0.32,95% confidence interval:0.13-0.77,P=0.011).CONCLUSION Increased 5-hmC is a favorable prognostic factor in GC,especially for ***-negative subgroups.