Role of cell-free DNA for predicting incidence and outcome of patients with ischemic stroke
作者机构：Central Laboratory for Stem Cell Research and Translational MedicineCentre for Liver Research and DiagnosticsDeccan College of Medical SciencesHyderabad 500058TelanganaIndia Department of NeurologyPrincess Esra HospitalDeccan College of Medical SciencesHyderabad 500002TelanganaIndia
出 版 物：《World Journal of Neurology》 (世界神经病学杂志)
年 卷 期：2022年第8卷第1期
页 面：1-9页
主 题：Ischemic stroke Mitochondria Circulating cell-free DNA Plasma nucleic acid Mortality
摘 要：Early diagnosis and prognosis of ischemic stroke remains a critical challenge in clinical settings.A blood biomarker can be a promising quantitative tool to represent the clinical manifestations in ischemic ***-free DNA(cfDNA)has recently turned out to be a popular circulating biomarker due to its potential relevance for diagnostic applications in a variety of *** bright outlook of cfDNA in clinical applications,very less is known about its origin,composition,or *** recent studies have identified cell-derived mitochondrial components including mitochondrial DNA(mtDNA)in the extracellular spaces including blood and cerebrospinal ***,the time course of alterations in plasma mtDNA concentrations in patients after an ischemic stroke is poorly *** is thought to be freed into the plasma shortly after the commencement of an ischemic stroke and then gradually ***,the importance of cell-free mtDNA(cf-mtDNA)in ischemic stroke is still *** review summarizes about the utility of biomarkers which has been standardized in clinical settings and role of cfDNA including cfmtDNA as a non-invasive potential biomarker of ischemic stroke.
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