Construction of fluorescent hyperbranched polysiloxane-based clusteroluminogens with enhanced quantum yield and efficient cellular lighting

作     者：Tian Bai Yunsheng Zhang Lan Wang Hongxia Yan Wenhao Zhou 

作者机构：Shaanxi Key Laboratory of Biomedical Metallic MaterialsNorthwest Institute for Non-Ferrous Metal ResearchXi’anP.R.China Key Laboratory of Polymer Science and Technology of Shaanxi ProvinceSchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anP.R.China 

出 版 物：《聚集体(英文)》 (Aggregate)

年 卷 期：2023年第4卷第2期

页      面：227-236页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:21875188,22175143,32101087 Key Research and Development Program of Shaanxi,Grant/Award Number:2021SF-297 Natural Science Foundation of Shaanxi Province,Grant/Award Numbers:2022JQ-312,CLGC202218 

主　　题：cell imaging fluorescence hyperbranched polysiloxane 

摘      要：Owing to its designability and intrinsic fluorescence,non-conjugated hyperbranched polysiloxane(HBPSi)has attracted widespread attention in biological filed,while it is still severely restricted by low fluorescence ***,in this paper,we introduced disulfide into HBPSi improving their luminescence properties and synthesized different molecular weight HBPSi(P1,P2,and P3).Surprisingly,P1 exhibited ultrahigh quantum yield up to 47.81%.Meanwhile,experiments applied with theoretical calculations were employed to explore the fluorescence mechanism,which is attributed to efficient restricting of non-radiative decay by clusteroluminogens formed with the cooperation of hyperbranched structure and double hydrogen *** addition,the biocompatibility of P1 was verified by co-culture with MC3T3-E1 and P1 lighted up mouse fibroblast cells without fluorescent *** work designed a novel fluorescent polymer with ultrahigh fluorescence quantum yield and cell imaging ability,which is promising in visualization diagnosis and treatment of tumor.