Synthesis and Anticandidosic Activities of Some 3-Imidazo[1,2-a]Pyridinyl-1-Arylpropenone Derivatives

作     者：Kouassi Francesco Adingra Souleymane Coulibaly Kacou Alain Mahama Ouattara Drissa Sissouma Kouassi Francesco Adingra;Souleymane Coulibaly;Kacou Alain;Mahama Ouattara;Drissa Sissouma

作者机构：Laboratoire de Constitution et Réaction de la Matière UFR Sciences des Structures de la Matière et Technologie Université Félix Houphouë t Boigny Abidjan Cô te d’Ivoire Département de Chimie Thérapeutique et Chimie organique UFR Sciences Pharmaceutiques et Biologiques Abidjan Cô te d’Ivoire 

出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)

年 卷 期：2022年第12卷第4期

页      面：81-91页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Imidazo[1 2-a]Pyridine Arylpropenone Candida albicans Antifungal 

摘      要：In this work, we show the synthesis of ten (10) new derivatives of 3-imidazo [1,2-a]pyridinyl-1-arylpropenone (10a - d). These new compounds were obtained by condensation of Claisen-Schmidt between derivatives of 2-substi- tuted-1H-imidazo[1,2-a]pyridine-3-carbaldehyde (3a - b and 7) and acetophenone derivatives (9a - e) in the presence of a base. The synthesized compounds were characterized by spectroscopic analyses 1H and 13C NMR. The antifungal activity of the ten (10) derivatives was determined on a resistant strain of Candida albicans by the microdilution method. The results showed that four (4) of them (10a, 10b, 10c and 10i) were active with minimum inhibitory concentrations (MICs) below 300 μmol/L. Of these four compounds, 10i was more potent than the others with a MIC of 41.98 μmol/L.