Tumor microenvironment in pancreatic ductal adenocarcinoma:Implications in immunotherapy
作者机构：Department of Pathology and Anatomical SciencesUniversity of Missouri School of MedicineColumbiaMO 65212United States Department of PathologyEmory University School of MedicineAtlantaGA 30322United State Eppley Institute for Research in Cancer and Allied DiseasesFred and Pamela Buffett Cancer CenterUniversity of Nebraska Medical CenterOmahaNE 68198United States Department of PathologyMicrobiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Department of Pathology and Laboratory MedicineKaiser Permanente Sacramento Medical CenterSacramentoCA 95825United States Department of Pathology and ImmunologyWashington UniversitySt.LouisMO 63110United States Department of Pathology and Anatomical SciencesUniversity of MissouriColumbiaMO 65212United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第27期
页 面：3297-3313页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pancreatic ductal adenocarcinoma Tumor microenvironment Immunotherapy Clinical trial Chemotherapy Treatment
摘 要：Pancreatic ductal adenocarcinoma is one of the most aggressive and lethal *** resection is the only curable treatment option,but it is available for only a small fraction of patients at the time of *** current therapeutic regimens,the average 5-year survival rate is less than 10%in pancreatic cancer *** has emerged as one of the most promising treatment options for multiple solid tumors of advanced ***,its clinical efficacy is suboptimal in most clinical trials on pancreatic *** studies have suggested that the tumor microenvironment is likely the underlying barrier affecting immunotherapy drug efficacy in pancreatic *** this review,we discuss the role of the tumor microenvironment in pancreatic cancer and the latest advances in immunotherapy on pancreatic cancer.
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