Probiotics and postbiotics in colorectal cancer:Prevention and complementary therapy
作者机构：Center of Clinical and Preclinical Research MEDIPARKFaculty of MedicineP.J.Safarik University in KosiceKosice 04011Slovakia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第27期
页 面：3370-3382页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Scientific Grant Agency of the Ministry of Education of Slovak Republic and Academy of Sciences VEGA,No.1/0393/20 the Operational Program Integrated Infrastructure Within the Project:Demand-Driven Research for the Sustainable and Innovative Food,Co-financed by the European Regional Development Fund,No.Drive4SIFood 313011V336
主 题：Colorectal cancer Traditional probiotics Next-generation probiotics Postbiotics Gut microbiota
摘 要：Colorectal cancer(CRC)is a leading cause of human mortality *** conventional anticancer therapy not always being effective,there is growing interest in innovative“drug-freecancer treatments or interventions that improve the efficacy of established *** is associated with microbiome alterations,a process known as dysbiosis that involves depletion and/or enrichment of particular gut bacterial species and their metabolic *** patient treatment with traditional probiotics(with or without prebiotics),nextgeneration probiotics(NGP),or postbiotics represents a potentially effective and accessible complementary anticancer strategy by restoring gut microbiota composition and/or by signaling to the *** this capacity,restoration of the gut microbiota in cancer patients can stabilize and enhance intestinal barrier function,as well as promote anticarcinogenic,anti-inflammatory,antimutagenic or other biologically important biochemical pathways that show high specificity towards tumor *** benefits of traditional probiotics,NGP,and postbiotics include modulating gut microbiota composition and function,as well as the host inflammatory *** application in CRC prevention is highlighted in this review,where we consider supportive in vitro,animal,and clinical *** on emerging research,NGP and postbiotics hold promise in establishing innovative treatments for CRC by conferring physiological functions via the production of dominant natural products and metabolites that provide new host-microbiota signals to combat *** favorable results have been reported,further investigations focusing on strain and dose specificity are required to ensure the efficacy and safety of traditional probiotics,NGP,and postbiotics in CRC prevention and treatment.
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