Spontaneous pain as a challenge of research and management in chronic pain
作者机构：Neuroscience Research Institute and Department of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijingChina Department of NeurobiologySchool of Basic Medical SciencesNeuroscience Research InstitutePeking University38 Xueyuan RoadBeijing 100083China Key Laboratory for NeuroscienceMinistry of Education/National Health CommissionPeking UniversityBeijing100083China
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2022年第2卷第3期
页 面：308-319页
学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100502[医学-中医临床基础] 10[医学] 100602[医学-中西医结合临床]
基 金：supported by the National Natural Science Foundation of China(31872774,82101303,81974166,81821092) Beijing Natural Science Foundation(7202083,5182013) the Interdisciplinary Medicine Seed Fund of Peking University(BMU2018MX011) China Postdoctoral Science Foundation(2020M670061)
主 题：behavioral measurement limbic system primary sensitization spontaneous pain
摘 要：Spontaneous pain occurring without apparent external stimuli,is a significant complaint of individuals with chronic pain whose mechanisms,somewhat surprisingly,remain poorly *** the past decades,neuroimaging studies start to reveal brain activities accompanying spontaneous ***,a variety of animal models and behavioral tests have been established,including non-reflexive tests and free-choice tests,which have been shown to be effective in assessing spontaneous *** the spontaneous pain mechanisms,multiple lines of research mainly focus on three aspects:(1)sensitization of peripheral nociceptor receptors and ion channels,(2)spontaneous neuronal firing and abnormal activity patterns at the dorsal root ganglion and spinal cord level,(3)functional and structural alterations in the brain,particularly the limbic system and the medial pain *** accumulating evidence revealing distinct neuronal mechanisms from evoked pain,we are still far from full understanding of spontaneous pain,leaving a big gap between bench and bedside for chronic pain treatment.A better understanding of the neural processes in chronic pain,with specific linkage as to which anatomical structures and molecules related to spontaneous pain perception and comorbidities,will greatly improve our ability to develop novel therapeutics.
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