Chemical and biological diversity of new natural products from marine sponges:a review(2009–2018)

作     者：Li‑Li Hong Ya‑Fang Ding Wei Zhang Hou‑Wen Lin 

作者机构：Research Center for Marine DrugsState Key Laboratoryof Oncogenes and Related GenesDepartment of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Food and PharmacyZhejiang Ocean UniversityZhoushan 316000China Centre for Marine Bioproducts DevelopmentFlindersUniversityAdelaideSA 5042Australia 

出 版 物：《Marine Life Science & Technology》 (海洋生命科学与技术（英文）)

年 卷 期：2022年第4卷第3期

页      面：356-372页

核心收录：

学科分类：070703[理学-海洋生物学] 07[理学] 0707[理学-海洋科学] 

基　　金：supported by the National Key Research and Development Program of China(No.2018YFC0310900) National Natural Science Foundation of China(Nos.22137006,41906075,and 41729002) China Postdoctoral Science Foundation(No.BX20180192) 

主　　题：Marine sponges New compounds Bioactivity Marine natural products 

摘      要：Marine sponges are productive sources of bioactive secondary metabolites with over 200 new compounds isolated each year,contributing 23%of approved marine drugs so *** review describes statistical research,structural diversity,and pharmacological activity of sponge derived new natural products from 2009 to *** 2762 new metabolites have been reported from 180 genera of sponges this decade,of which the main structural types are alkaloids and terpenoids,accounting for 50%of the *** than half of new molecules showed biological activities including cytotoxic,antibacterial,antifungal,antiviral,anti-inflammatory,antioxidant,enzyme inhibition,and antimalarial *** summarized in this review,macrolides and peptides had higher proportions of new bioactive compounds in new compounds than other chemical *** chemical class displayed cytotoxicity as the dominant *** were the major contributors to antibacterial,antifungal,and antioxidant activities while steroids were primarily responsible for pest resistance ***,terpenoids,and steroids displayed the most diverse biological *** statistic research of new compounds by published year,chemical class,sponge taxonomy,and biological activity are *** novelty and significant bioactivities of some representative compounds are *** sponges are rich sources of novel bioactive compounds and serve as animal hosts for microorganisms,highlighting the undisputed potential of sponges in the marine drugs research and development.