Electroacupuncture attenuates chronic salpingitis via transforming growth factor-β1/p38 mitogen-activated protein kinase signaling pathway

作     者：HU Xijiao CHENG Yinglong KANG Huanan LI Shuoxi WANG Yawen LIU Jinzhe SUN Yiming LIU Li HU Xijiao;CHENG Yinglong;KANG Huanan;LI Shuoxi;WANG Yawen;LIU Jinzhe;SUN Yiming;LIU Li

作者机构：Department of obstetrics and gynecologythe Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHeilongjiang 150001China Deapartment of Hysteroscopy chamberthe First Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin 150040China College of pharmacyHeilongjiang University of Chinese MedicineHarbin 150040China Midwifery Teaching and Research SectionHeilongjiang University of Chinese Medicine Jiamusi CollegeHarbin 150040China The department of obstetrics and gynecologythe First Affiliated Hospital of Henan University of Chinese MedicineHenan 450000China Department of Chinese PharmacySchool of PharmacyGuizhou University of Chinese MedicineGuizhou 550000China Andrology department Heilongjiang Academy of Traditional Chinese MedicineHarbin 150036China Endoscopy roomthe First Affiliated Hospital of Heilongjiang University of Traditional Chinese MedicineHysteroscopy DepartmentHarbin 150040China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2022年第42卷第5期

页      面：781-787页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by the Scientific Research Project of Heilongjiang Administration of Traditional Chinese Medicine(ZHY18-087):Clinical Study on the Treatment of Tubal Inflammatory Infertility with Gexia Zhuyu Decoction Combined with Hysteroscopic Tubal Fluid Passage Natural Science Foundation of Heilongjiang Province(H2015026):Study on the Effect of Activating Blood Circulation and Removing Blood Stasis,Activating Qi and Relieving Pain on Salpingitis Infertile Rat Model Mechanism of Gexia Zhuyu Decoction Improved Fallopian Tube Fibrosis in the Treatment of Salpingitic Obstructive Infertility based on Transforming Growth Factor-Β1/Phosphorylation38 Mitogen-Activated Protein Kinase Pathway(2021ZYGLG001) 

主　　题：electroacupuncture salpingitis transforming growth factor beta1 mitogen-activated protein kinase 

摘      要：OBJECTIVE:To explore the effect of electroacupuncture(EA)on rats with chronic fallopian tube inflammation and its potential ***:Thirty-six female Sprague-Dawley rats were divided into Control,Model and EA *** pathological morphology of the fallopian tubes was observed by hematoxylin-eosin(HE)and Masson *** results of transforming growth factor-β1(TGF-β1),P38 mitogen-activated protein kinase(MAPK),phosphorylation(p)-p38MAPK in rat oviduct tissues were detected by *** of P38MAPK,p-P38MAPK and TGF-β1 in rat oviduct tissues were detected by *** expression level of p38MAPK,p-P38MAPK,TGF-β1 protein in rats was detected by Western *** real-time polymerase chain reaction(RT-q PCR)was used to detect m RNA expression levels of TGF-β***:It found that collagen fibers counts decreased significantly in EA group compared to Model *** phosphorylation of P38MAPK in EA group was significantly reduced compared to Model *** serum TGF-β1 expressions in EA group increased decreased ***:Electroacupuncture was able to attenuate chronic salpingitis through down-regulating TGF-β1/MAPK signaling pathway.