Exploring the Action Mechanism of Yadanzi(Brucea javanica)in the Treatment of Glioblastoma Based on Bioinformatics and Network Pharmacology

作     者：Wenyu Zhao Fuchun Si 赵雯宇;司富春

作者机构：Cllege of Chinese MedicineHenan University of Chinese MedicineZhengzhouHenanChina Academy of Chinese Medicine ScienceHenan University of Chinese MedicineZhengzhouHenanChina 

出 版 物：《Chinese Medicine and Natural Products》 (中医学报（英文）)

年 卷 期：2022年第2卷第2期

页      面：67-76页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Yadanzi(Brucea javanica) glioblastoma bioinformatics network pharmacology action mechanism 

摘      要：ObjectiveThe aim of the study is to explore the molecular mechanism of Yadanzi(Brucea javanica)in the treatment of glioblastoma(GBM)by using the methods of bioinformatics and network *** The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and literature retrieval method were applied to obtain the active ingredients of Yadanzi(Brucea javanica),and to predict the relevant targets of the active *** GBM-related targets were retrieved and screened through the Gene Expression Profling Interactive Analysis(GEPIA)database,and mapped to each other with the targets of the components of Yadanzi(Brucea javanica)to obtain the intersection *** GBM differentially expressed gene targets were imported into the String database to obtain the protein interaction relationship,the Cytoscape software was used to draw the protein interaction network,the Cytobba and MCODE plug-ins were used to screen the core genes and important protein interaction modules,and the GEPIA database was applied to make survival analysis of the core *** network map of“active ingredients-targetswas constructed through the Cytoscape 3.6.1 *** Ontology(GO)biological function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathway enrichment analysis for GBM differentially expressed genes were performed through the DAVID *** TCMSP and literature retrieval,23 potential active ingredients and 129 related targets were obtained from Yadanzi(Brucea javanica).In the GEPIA database,247 GBM differentially expressed genes were screened,including 113 upregulated genes and 134 downregulated *** mapping with the targets related to the active ingredients of Yadanzi(Brucea javanica),six intersection targets were obtained,that is,the potential action targets of Yadanzi(Brucea javanica)in treating GBM,including MMP2,HMOX1,BIRC5,EGFR,CCNB2,and *** software was applied to