Development of environment-insensitive and highly emissive BODIPYs via installation of N,N'-dialkylsubstituted amide at meso position

作     者：Junping Bai Junliang Zhou Xin Ji Nannan Wang Xiaochun Dong Wei Wu Weili Zhao Junping Bai;Junliang Zhou;Xin Ji;Nannan Wang;Xiaochun Dong;Wei Wu;Weili Zhao

作者机构：School of PharmacyInstitutes of Integrative MedicineFudan UniversityShanghai 201203China Key Laboratory for Special Functional Materials of Ministry of EducationSchool of Materials Science and EngineeringHenan UniversityKaifeng 475004China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第9期

页      面：4175-4178页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(No.82030107)。 

主　　题：Fluorescent dyes BODIPY Environment-insensitive Bioimaging 

摘      要：Fluorescent dyes play a crucial role in fluorescence imaging and sensing technology.However,there is a dilemma that they are usually intrinsically hydrophobic which lacks of emission in water and modification with ionic groups to access water solubility may result in poor membrane permeability.Fluorescent dyes with strong fluorescence emission in both nonpolar and polar solvents are highly desirable.In this manuscript,we reported a strategy to develop fluorescent BODIPY dyes via installation of amide moiety at meso position of 1,3,5,7-tetramethyl-BODIPY and discovered that N,N -dialkylsubstituted BODIPY amides possessed highly fluorescent emission with favorable environment-insensitive properties.