Ligand-Controlled Palladium-Catalyzed Regiodivergent Defluorinative Allylation of gem-Difluorocyclopropanes viaσ-Bond Activation
作者机构：State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210093 China School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2022年第40卷第19期
页 面：2345-2355页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the National Natural Science Foundation of China(Grants 22025104,21972064 and 21901111) the Fundamental Research Funds for the Central Universities for their financial support(Grant 020514380254) The project was also supported by Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University
主 题：Allylation C-C activation Cross-coupling gem-Difluorocyclopropanes Defluorination
摘 要：Monofluoroalkenes are important and versatile privileged components in pharmacologically relevant ***,we report a method for the selective construction of these compounds in a diversity-oriented fashion through regiodivergent cross-coupling of gem-difluorocyclopropanes with allylboronates by employing a palladium catalyst with two different ligands,in which gem-difluorocyclopropanes were used as allyl electrophiles by C—C and C—F bond *** the presence of 2-biphenylyl(diphenyl)phosphine as ligand,the linear-selective allyl–allyl bond formation is highly obtained,while utilizing the sterically hindered BrettPhos(dicyclohexyl[3,6-dimethoxy-2 ,4 ,6 -tris(1-methylethyl)[1,1 -biphenyl]-2-yl]phosphine)as the ligand favors the generation of the branched-selective *** and computational studies investigated the key steps of the cross-coupling reactions,revealing the origin of the ligand-controlled regiodivergence.
维普期刊数据库