Human Endogenous Retroviruses and Hematological Malignant Tumors
作者机构：Department of AIDS ResearchState Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyBeijingChina
出 版 物：《Infectious Microbes & Diseases》 (感染微生物与疾病（英文）)
年 卷 期：2022年第4卷第2期
页 面：56-63页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：human endogenous retrovirus hematologic malignant tumor Np9 gene
摘 要：Human endogenous retrovirus(HERV)gene sequences are remnants of retroviruses that infected the ancestors of humans millions of years ago and were integrated into human chromosomes,accounting for approximately 8%-9%of the human *** integrated HERVs have lost their coding capacity and remain silent due to frame shifts,mutations,and sequence deletions or insertions over the millions of years,but their expression is highly regulated by epigenetic and host defense ***,there are still some HERV genes that have intact open reading frames due to recent integration into the human genome or positive selective *** abnormal activation of HERVs may contribute to diseases or their pathology,such as malignant tumors,autoimmune diseases,and nervous system *** occurrence and development of hematological malignant tumors(HMTs)is a complex process involving interactions of multiple genetic and environmental *** abnormal activation of HERVs may contribute to the pathology of HMTs via indirect *** this review,we address the discovery of endogenous retroviruses in vertebrates,and the classification and genomic structure of *** HERV family members,HERV-K is the latest type of HERV integrated into the human genome and it has the strongest transcriptional *** explore the currently known expression of HERV-K proto-oncogenes in HMTs and further address potential research and therapeutic ***,much remains to be learned about not only the impact of HERVs on the occurrence of HMTs,but also the potential value of HERVs as diagnostic and therapeutic targets for HMTs.
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