Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging

作     者：Huqing Wang Haiqin Wu Hena Guo Guilian Zhang Ru Zhang Shuqin Zhan 

作者机构：Department of Neurology Second Affiliated Hospital of Medical College Xi＇an Jiaotong University Xi＇an 710004 Shaanxi Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第10期

页      面：778-782页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 071002[理学-动物学] 

基　　金：supported by grants from Foundation of Second Hospital of Medical College of Xi’an Jiaotong University, No. 2005-yl-01 the National Natural Science Foundation of China (The mechanism of erythropoietin-TAT regulating Keap l-Nrf2 pathway on anti-aging process in nerve,2011), No. 81170330 

主　　题：aging brain hypoxia-inducible factor 1α Nissl body behavior 

摘      要：The present study observed changes in rat neural cells at various ages （3, 18, 24, and 30 months）. With age, neural cells became large and were sparsely arranged, and the number of Nissl bodies decreased. In addition, hypoxia-inducible factor 1α expression increased with increasing age in hippocampal CA1 and CA3 regions, motor cortex, and the first subfolium, especially from 3 to 18 months. In the open-field test, grid crossing decreased with increasing age, especially from 18 months. The number of rearings reached a peak in the 18 months group, and then subsequently decreased. The results suggested that hypoxia-inducible factor 1α played an important role in the nervous system aging process.