孔源性视网膜脱离的遗传风险:一项家族聚集性研究
Genetic risk of rhegmatogenous retinal detachment a familial aggregation study作者机构：Department of Ophthalmology 813University Medical Centre Nijmegen PO Box 9101 Nijmegen 6500 HB Netherlands Dr
出 版 物：《世界核心医学期刊文摘(眼科学分册)》 (Digest of the World Core Medical Journals)
年 卷 期：2006年第1期
页 面：29-29页
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
摘 要：Objective: To investigate the magnitude of the genetic risk of nonsyndromic rhegmatogenous retinal detachments (RRDs) in a familial aggregation study. Design: Two hundred three consecutive patientswith RRD and 461 controlswithout RRD were ascertained at the Department of Ophthalmology of the University Medical Centre Nijmegen in Nijmegen, the Netherlands. Data on family composition, history of RRD, and presence of other risk factors in siblings and offspring were collected by means of a questionnaire. Diagnosis of RRD was confirmed by evaluation of medical records. Results: One hundred eightyone patients (89.2% of those eligible) and 408 controls (88.5% of invited controls) with 1090 and 2345 relatives, respectively, were included in the analysis. Thirteen familial RRDs (1.2% )-were diagnosed in 10 case probands and 9 RRDs (0.4% ) in 8 control probands. Siblings and offspring of cases had a higher incidence of RRD independent of age, sex, and myopia. The cumulative lifetime risk of RRD was 7.7% for relatives of cases and 3.0% for relatives of controls, yielding a risk ratio of 2.6 (95% confidence interval, 1.1-6.2). Conclusions: Familial occurrence of RRD is a risk factor for RRD. Genetic factors apart from myopia may explain the increased familial risk.
同方期刊数据库