Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes

作     者：Ping Lin Xue Li Yuchen Xin Hongying Li Gang Li Hongxiang Lou 

作者机构：Department of Natural Medicinal Chemistry and PharmacognosySchool of PharmacyQingdao UniversityQingdao 266071China Department of Natural Product ChemistryKey Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China 

出 版 物：《Engineering Microbiology》 (工程微生物学（英文）)

年 卷 期：2022年第2卷第3期

页      面：37-46页

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.81903494) the Scientific Research Foun-dation of Qingdao University 

主　　题：Natural products Rubromycins Spiroketal Biosynthesis Bioactivity 

摘      要：Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse fam-ily of polycyclic *** of them are consequently suggested as lead structures for drug *** them,rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannu-lated[5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin *** type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities,includ-ing antimicrobial,anticancer,and enzyme inhibition *** unique structures,intriguing biosynthesis,and marked bioactivities of rubromycins have drawn considerable attention from several chemists and *** review covers the isolation,characterization,biosynthesis,and biological studies of these structurally diverse and complex rubromycins.