Network pharmacological study of Zuogui pill and Yougui pill for the treatment of postmenopausal osteoporosis

作     者：Jie Ding Shan-Shan Mei Zhe-Xin Ni Chao-Qin Yu 

作者机构：Department of TCM GynecologySchool of Traditional Chinese MedicineNaval Medical UniversityShanghai 200433China Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200433China 

出 版 物：《Aging Communications》 (衰老通讯)

年 卷 期：2022年第4卷第3期

页      面：4-13页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Science and Technology Commission of Shanghai Municipality China(20Z21900400) 

主　　题：Zuogui pill Yougui pill postmenopausal osteoporosis network pharmacological 

摘      要：Background:Postmenopausal osteoporosis(PMO)is the most common primary osteoporosis in older *** condition imposes a huge economic and medical burden on *** from western medicine,traditional Chinese medicine is also widely used for the treatment of PMO,especially in Asian *** pill(ZGP)and Yougui pill(YGP)are classical formulas for the treatment of PMO with potent clinical *** study aimed to explore the potential active compounds,potential targets,and potential mechanisms of ZGP and YGP for the treatment of ***:Compounds from ZGP and YGP were collected from three online databases,and these compounds were screened by oral bioavailability and *** corresponding targets were determined from the Medicine Systems Pharmacology Database and Analysis *** corresponding targets for PMO were obtained from two disease *** target protein-protein interaction was identified through the STRING platforms and the core targets were ascertained by analyzing the protein-protein interaction network by using Cytoscape ***-related genes were identified via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses to identify specific biological processes,cellular components,molecular functions and key signalling pathways of ZGP and YGP for PMO ***:A total of 68 compounds were screened from ZGP with 168 putative potential target genes,whereas 99 compounds were screened from YGP with 214 potential target genes associated with *** of the core components included quercetin and kaempferol,and most of the core targets were TP53,AKT1,MAPK1,JUN,TNF,HSP90AA1,APP,IL6,VEGFA,RELA,MAPK8,NR3C1,EGFR,CXCL8,ESR1,FOS and *** Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that ZGP and YGP treat PMO primarily via regulation of bone formation and resorption,anti-inflammatory immunity and hormonal ***:Our data provided insights i