The chromatin remodeler BRAHMA recruits HISTONE DEACETYLASE6 to regulate root growth inhibition in response to phosphate starvation in Arabidopsis

作     者：Tao Li Ruyue Zhang Viswanathan Satheesh Peng Wang Guojie Ma Jianfei Guo Guo-Yong An Mingguang Lei Tao Li;Ruyue Zhang;Viswanathan Satheesh;Peng Wang;Guojie Ma;Jianfei Guo;Guo-Yong An;Mingguang Lei

作者机构：Shanghai Center for Plant Stress BiologyCAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Crop Stress Adaptation and ImprovementSchool of Life SciencesHenan UniversityKaifeng 475004China 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2022年第64卷第12期

页      面：2314-2326页

核心收录：

学科分类：09[农学] 0903[农学-农业资源与环境] 

基　　金：the Shanghai Natural Science Foundation(22ZR1469200) the National Natural Science Foundation of China(31970580) 

主　　题：BRM histone deacetylation phosphate starvation root development 

摘      要：Plasticity in root system architecture(RSA)allows plants to adapt to changing nutritional status in the *** availability is a major determinant of crop yield,and RSA remodeling is critical to increasing the efficiency of phosphorus *** substantial progress has been made in understanding the signaling mechanism driving phosphate starvation responses in plants,whether and how epigenetic regulatory mechanisms contribute is poorly ***,we report that the Switch defective/sucrose non-fermentable(SWI/SNF)ATPase BRAHMA(BRM)is involved in the local response to phosphate(Pi)*** loss of BRM function induces iron(Fe)accumulation through increased LOW PHOSPHATE ROOT1(LPR1)and LPR2 expression,reducing primary root length under Pi *** also demonstrate that BRM recruits the histone deacetylase(HDA)complex HDA6-HDC1 to facilitate histone H3 deacetylation at LPR loci,thereby negatively regulating local Pi deficiency *** is degraded under Pi deficiency conditions through the 26 S proteasome pathway,leading to increased histone H3 acetylation at the LPR ***,our data suggest that the chromatin remodeler BRM,in concert with HDA6,negatively regulates Fe-dependent local Pi starvation responses by transcriptionally repressing the RSA-related genes LPR1 and LPR2 in Arabidopsis thaliana.