Dynamic mechanism of GPCR-mediated β-arrestin:a potential therapeutic agent discovery of biased drug

作     者：Zheng Xu Zhenhua Shao 

作者机构：Division of Nephrology and Kidney Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University610041 ChengduSichuanChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第9期

页      面：3155-3157页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(32070049) Science and Technology department of Sichuan Province 2020YJ0208 the China Postdoctoral Science Foundation BX20220219 

主　　题：agent Dynamic activation 

摘      要：Recently,a study published in Cell by Asher and colleagues,discovered theβ-arrestin-1(βarr-1)activation could be mediatedby its C-terminal tail,the activation of targeted receptor andpattern of phosphorylation at the C-tail of receptor,based on asingle molecule fluorescence resonance energy transfer imagingstrategy.