Frequency-Resolved Connectome Hubs and Their Test-Retest Reliability in the Resting Human Brain
作者机构：State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijing 100875China Beijing Key Laboratory of Brain Imaging and ConnectomicsBeijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China Institute of Science and Technology for Brain-Inspired IntelligenceFudan UniversityShanghai 200433China Key Laboratory of Computational Neuroscience and BrainInspired Intelligence(Fudan University)Ministry of EducationShanghai 200433China School of Systems ScienceBeijing Normal UniversityBeijing 100875China Chinese Institute for Brain ResearchBeijing 102206China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2022年第38卷第5期
页 面：519-532页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学]
基 金：The study was supported by the National Key R&D Program of China(2018YFA0701402) the National Natural Science Foundation of China(82021004,81971690,81620108016,and 11835003) the Fundamental Research Funds for the Central Universities of China(2019NTST24).
主 题：Connectome Hubs Frequency Degree centrality Test-retest reliability
摘 要：Functional hubs with disproportionately extensive connectivities play a crucial role in global information integration in human brain networks.However,most resting-state functional magnetic resonance imaging(R-fMRI)studies have identified functional hubs by examining spontaneous fluctuations of the blood oxygen level-dependent signal within a typical low-frequency band(e.g.,0.01–0.08 Hz or 0.01–0.1 Hz).Little is known about how the spatial distributions of functional hubs depend on frequency bands of interest.Here,we used repeatedly measured R-fMRI data from 53 healthy young adults and a degree centrality analysis to identify voxelwise frequency-resolved functional hubs and further examined their test-retest reliability across two sessions.We showed that a wide-range frequency band(0.01–0.24 Hz)accessible with a typical sampling rate(fsample=0.5 Hz)could be classified into three frequency bands with distinct patterns,namely,low-frequency(LF,0.01–0.06 Hz),middle-frequency(MF,0.06–0.16 Hz),and high-frequency(HF,0.16–0.24 Hz)bands.The functional hubs were mainly located in the medial and lateral frontal and parietal cortices in the LF band,and in the medial prefrontal cortex,superior temporal gyrus,parahippocampal gyrus,amygdala,and several cerebellar regions in the MF and HF bands.These hub regions exhibited fair to good test-retest reliability,regardless of the frequency band.The presence of the three frequency bands was well replicated using an independent R-fMRI dataset from 45 healthy young adults.Our findings demonstrate reliable frequency-resolved functional connectivity hubs in three categories,thus providing insights into the frequency-specific connectome organization in healthy and disordered brains.
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