The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis
作者机构：Department of Occupational and Environmental MedicineSchool of Public HealthWuhan University of Science and TechnologyWuhan 430065China Center of Scientific Research and ExperimentNanyang Medical CollegeNanyang 473006China Department of PhysiologyWayne State University School of MedicineDetroitMI 48201USA Department of Obstetrics and GynecologyWayne State University School of MedicineDetroitMI 48201USA
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2022年第24卷第3期
页 面：238-242页
核心收录：
基 金：supported by the Natural Science Foundation of Hubei Province(Excellent Youth Foundation,No.2018CFA040) the Outstanding Young and Middle-aged Technology Innovation Team Project of the Hubei Provincial Department of Education(No.T2020003) NIH grant(No.HD076257) Wayne State University Start-up fund.
主 题：IFT25 cilium hedgehog signaling intraflagellar transport spermatogenesis
摘 要：Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling compartment.During ciliogenesis,ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport(IFT)particles,where the inner counterparts undergo reverse trafficking.The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction.Much progress has been made on the mechanisms and functions of IFT;however,recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis.In this review,we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.
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