The characterization of transmembrane protein 59-like(TMEM59L)reveals its role in the regulating the level of the GDI protein family
作者机构：School of Environmental EngineeringCentral Plains Specialty Food Engineering&Technology Research CenterKaifeng Key Laboratory of Food Composition and Quality AssessmentYellow River Conservancy Technical InstituteKaifeng475004China Laboratory of Molecular Neural BiologySchool of Life SciencesShanghai UniversityShanghai200444China
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2022年第46卷第12期
页 面：2615-2624页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：This work was supported by the Science and Technology Development Plan of Kaifeng in 2020(2003048) the National Natural Science Foundation of China(Grant No.31070954)
主 题：TMEM59L Localization GDI1 GDI2 Protein processing
摘 要：The characterization and functions of transmembrane protein 59-like(TMEM59L),a type I transmembrane protein,are not clearly understood until *** TMEM59L and fluorescent fusion proteins constructs were transfected in cell lines and liposomes,and their localization was *** effects of protein constructs were studied by fluorescence microscopy and western *** study reports a novel function of human TMEM59L(hTMEM59L)related to the expression and location of some *** addition,we report two novel splice variants of human TMEM59L(hTMEM59L).The localization of mutants of this protein,lacking a middle region,and a Cterminal deletion,markedly differed from that of full-length *** movement assessment in living cells showed the localization of TMEM59L to vesicular structures in the Golgi bodies,and the cell membrane was observed in living *** of TMEM59L markedly increased the level of amyloid precursor protein because of TMEM59L-mediated inhibition of cell membrane transport but did not affect the expression of betasecretase ***59L overexpression also significantly increased the levels of Rab GDP dissociation inhibitor alpha and Rab GDP dissociation inhibitor beta *** results suggest that TMEM59L is involved in the packaging of acidic vesicles and thereby functions in the trafficking and processing of intracellular proteins.
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