A need for stratification of metastasis samples according to secondary site in gene expression studies

作     者：IVANA SAMARŽIJA 

作者机构：Laboratory for EpigenomicsDivision of Molecular MedicineRuđer BoškovićInstituteZagreb10000Croatia Laboratory for Cell Biology and SignalingDivision of Molecular BiologyRuđer BoškovićInstituteZagreb10000Croatia 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2022年第46卷第7期

页      面：1747-1750页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by MY ZABA START 2019 donation from Zagrebačka banka:https://www.zaba.hr/home/en/about-us/community-involvement/my-zabastart The funder had no role in study design,data collection,analysis,and interpretation,decision to publish,or preparation of the manuscript. 

主　　题：Bone metastasis Brain metastasis Liver metastasis Lung metastases Gene expression 

摘      要：Comparisons of gene expression profiles between primary tumors and metastasis have revealed genes that are implicated in metastasis formation.However,gene expression studies conducted on metastasis samples from the same primary site usually do not discriminate between different secondary sites.Although the change in the expression of number of genes is expected to be common to metastasis from the same primary but different secondary sites,herein the data that point to substantial differences are presented.Furthermore,the reciprocal communication between metastatic and host cells that is influencing these differences is outlined to emphasize the need for stratification of metastasis samples in gene expression studies.